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KMID : 0379520200360010069
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한국독성학회지
2020 Volume.36 No. 1 p.69 ~ p.77
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Action mechanism of anti-wrinkle effect of Rhamnus yoshinoi methanol extract in human dermal fibroblast and keratinocyte cell lines
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Kim Hyun-Ok
Shin Kyoung-Ran
Jang Byeong-Churl
Kim Young-Chul
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Abstract
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Rhamnus yoshinoi is a deciduous broad-leaf bush and endemic species widely found in Korea. Recently, we reported that R. yoshinoi methanol extract (RYME) had excellent antioxidant activity and inhibition of collagenase and elastase activity in cell-free system. In this study, we investigated the ability of RYME to control the mRNA and protein expression levels of the known skin wrinkle-related factors in cultured human dermal fibroblast and keratinocyte cell lines. Treatment with 100 or 200 μg/mL RYME strongly blocked the UVB-induced downregulation of type 1 collagen mRNA expression (p?
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KEYWORD
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Anti-wrinkle effect, CCD-986sk cells, ERK-1/2 protein phosphorylation, HaCaT cells, MMP-3, Rhamnus yoshinoi
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